The enhancement of contextual fear conditioning by ABT-418
نویسندگان
چکیده
منابع مشابه
Contextual fear conditioning in zebrafish.
Zebrafish are a genetically tractable vertebrate that hold considerable promise for elucidating the molecular basis of behavior. Although numerous recent advances have been made in the ability to precisely manipulate the zebrafish genome, much less is known about many aspects of learning and memory in adult fish. Here, we describe the development of a contextual fear conditioning paradigm using...
متن کاملPrefrontal neuronal circuits of contextual fear conditioning.
Over the past years, numerous studies have provided a clear understanding of the neuronal circuits and mechanisms involved in the formation, expression and extinction phases of conditioned cued fear memories. Yet, despite a strong clinical interest, a detailed understanding of these memory phases for contextual fear memories is still missing. Besides the well-known role of the hippocampus in en...
متن کاملEstrogen modulates sexually dimorphic contextual fear conditioning
The present study examined the role of ovarian steroids in contextual fear conditioning and hippocampal synaptic plasticity in female rats. In experiment 1, adult female rats were ovariectomized and submitted to contextual fear conditioning, a procedure in which rats received unsignaled footshock in a novel observation chamber; freezing behavior served as the measure of conditional fear. Ovarie...
متن کاملThe role of calsenilin/DREAM/KChIP3 in contextual fear conditioning.
Potassium channel interacting proteins (KChIPs) are members of a family of calcium binding proteins that interact with Kv4 potassium (K(+)) channel primary subunits and also act as transcription factors. The Kv4 subunit is a primary K(+) channel pore-forming subunit, which contributes to the somatic and dendritic A-type currents throughout the nervous system. These A-type currents play a key ro...
متن کاملSpectral characteristics of the hippocampal LFP during contextual fear conditioning.
OBJECTIVE The hippocampus has an important role in the acquisition and recall of aversive memories. The objective of this study was to investigate the relationship among hippocampal rhythms. METHODS Microeletrodes arrays were implanted in the hippocampus of Wistar rats. The animals were trained and tested in a contextual fear conditioning task. The training consisted in applying shocks in the...
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ژورنال
عنوان ژورنال: Behavioural Pharmacology
سال: 2010
ISSN: 0955-8810
DOI: 10.1097/fbp.0b013e32833a5b9d